Understanding REACH Regulation (EC) 1907/2006: A Comprehensive Overview
The REACH Regulation (EC) 1907/2006, which stands for Registration, Evaluation, Authorisation, and Restriction of Chemicals, is one of the most significant pieces of legislation regarding chemical safety in the European Union (EU). Enacted in 2007, the regulation aims to improve the protection of human health and the environment from the risks posed by chemicals, while enhancing the EU’s competitiveness in the global chemicals market.
REACH plays a pivotal role in ensuring that companies within the EU properly manage the chemicals they manufacture or import, promoting the safe use of substances throughout their lifecycle, from production to disposal. This article provides a comprehensive overview of the REACH Regulation, explaining its main components, objectives, and implications for businesses operating in the EU.
REACH Background and Objectives
The REACH Regulation was developed in response to growing concerns over the increasing use of chemicals and their potential impact on human health and the environment. Prior to REACH, the regulation of chemicals in the EU was fragmented, with individual laws governing specific substances and risks. REACH consolidated and streamlined these regulations into a single, coherent framework aimed at:
1. Ensuring human health and environmental protection: REACH mandates that manufacturers and importers identify and manage the risks associated with chemicals in their products.
2. Promoting alternative testing methods: The regulation encourages the use of alternative, non-animal testing methods wherever possible to reduce animal testing in chemical safety evaluations.
3. Enhancing industry responsibility: REACH places the burden of safety data collection and risk management on companies, ensuring they are responsible for the chemicals they place on the market.
4. Fostering innovation and competitiveness: By improving chemical safety, REACH aims to maintain and improve the competitiveness of the European chemical industry.
Key Components of REACH
REACH is structured around four primary pillars: registration, evaluation, authorisation, and restriction. Below is an in-depth look at each component.
1. Registration
Under REACH, companies that manufacture or import chemicals into the EU in quantities greater than one tonne per year are required to register those chemicals with the European Chemicals Agency (ECHA). The registration process involves submitting detailed information about the substance, including its properties, uses, potential hazards, and risk management measures.
The purpose of registration is to ensure that chemical safety data is made available for evaluation by authorities and that the public is informed about the risks associated with chemicals. It also enables companies to ensure their chemicals are used safely and comply with the regulation.
2. Evaluation
The evaluation process under REACH is designed to assess the information submitted by registrants to ensure it is sufficient and reliable. The European Chemicals Agency (ECHA) and member state authorities are responsible for the evaluation of chemical dossiers. This evaluation aims to:
• Ensure that the risk assessments for chemicals are based on sound scientific evidence.
• Identify substances of concern: If concerns are raised about a substance’s risk to human health or the environment, further testing or restrictions may be required.
The evaluation process can lead to requests for additional information, or even restrictions on the use of certain chemicals if they are deemed dangerous.
3. Authorisation
The authorisation process is particularly important for chemicals that are classified as substances of very high concern (SVHCs). These substances may pose serious risks to health and the environment. Once a substance is identified as an SVHC, it is included in a candidate list for authorisation. Companies that wish to continue using or marketing these substances must apply for authorisation from ECHA.
The authorisation procedure allows the EU to progressively phase out the most hazardous chemicals and replace them with safer alternatives, thereby fostering innovation and pushing industry towards more sustainable chemical practices.
4. Restriction
REACH also provides for the restriction of certain substances. If a chemical poses an unacceptable risk to human health or the environment, restrictions can be placed on its manufacture, sale, or use within the EU. Restrictions can vary in scope, from complete bans to limitations on how the substance is used.
This aspect of REACH is particularly useful for controlling chemicals that are deemed particularly hazardous or for which safer alternatives are available, reducing the overall burden of dangerous chemicals in the market.
Impact on Businesses
The implementation of REACH brings about several significant changes for businesses operating in the EU, especially for manufacturers and importers of chemicals. Here are some of the key ways in which businesses are affected:
1. Registration Costs: Registration can be an expensive and time-consuming process. Companies need to ensure that they have sufficient data on the chemicals they are dealing with and may need to invest in additional testing or research. In some cases, the costs may be particularly burdensome for small and medium-sized enterprises (SMEs).
2. Supply Chain Implications: Companies must ensure that their suppliers also comply with REACH, which means that businesses must gather and evaluate safety information from their suppliers to ensure the substances they receive are REACH-compliant.
3. Data Management and Documentation: REACH requires extensive documentation of chemical safety data. Companies must keep track of the substances they manufacture or import and maintain records of risk assessments, safety data sheets, and other necessary documentation. Failure to comply with these requirements can lead to penalties, product recalls, or a ban on selling certain chemicals in the EU.
4. Innovation Opportunities: While REACH can present challenges for companies, it also creates opportunities for innovation. Businesses that can find safer alternatives to hazardous chemicals or develop processes that minimise chemical risks may have a competitive advantage in the market.
Enforcement and Compliance
The enforcement of REACH regulations is carried out by national authorities in each EU member state. These authorities have the power to inspect companies, carry out checks, and impose penalties on non-compliant businesses. The penalties can include fines, restrictions on product sales, and even criminal prosecution in extreme cases.
To ensure compliance, businesses must be proactive in understanding the requirements of REACH and establishing effective compliance management systems. This may involve consulting with experts, attending workshops, or utilising software tools designed to track compliance with REACH.
Conclusion
The REACH Regulation (EC) 1907/2006 represents a milestone in chemical safety regulation. By establishing stringent requirements for the registration, evaluation, authorisation, and restriction of chemicals, it ensures that both human health and the environment are protected from the dangers posed by hazardous substances.
While REACH presents challenges, especially for businesses that must navigate complex compliance requirements, it also fosters innovation and promotes the development of safer chemicals. In this way, REACH not only helps protect European citizens and the environment but also strengthens the EU’s position as a leader in sustainable chemical practices on the global stage.
For companies operating within or trading with the EU, staying informed about REACH’s evolving provisions is crucial to maintaining compliance and minimising business risks. By proactively adhering to these regulations, businesses can continue to thrive while contributing to a safer and more sustainable chemical industry.
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Candidate List of substances of very high concern (SVHC) for Authorisation as updated 25-06-2025
Registration, Evaluation, Authorisation, and Restriction of Chemicals REACH Update 2025
| Substance name Note: Group entries are split in different rows | Description | EC No. | CAS No. | Reason for inclusion | Date of inclusion | Remarks |
|---|---|---|---|---|---|---|
| Dibutylbis(pentane-2,4-dionato-O,O')tin | 245-152-0 | 22673-19-4 | Toxic for reproduction (Article 57c) | 25/06/2020 | ||
| Butyl 4-hydroxybenzoate | 202-318-7 | 94-26-8 | Endocrine disrupting properties (Article 57(f) - human health) | 25/06/2020 | ||
| 2-methylimidazole | 211-765-7 | 693-98-1 | Toxic for reproduction (Article 57c) | 25/06/2020 | ||
| 1-vinylimidazole | 214-012-0 | 1072-63-5 | Toxic for reproduction (Article 57c) | 25/06/2020 | ||
| Perfluorobutane sulfonic acid (PFBS) and its salts | - | - | Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health)#Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment) | 16/01/2020 | The combined intrinsic properties justifying the inclusion as a substance for which there is scientific evidence of probable serious effects to human health and the environment which give rise to an equivalent level of concern are the following: very high persistence, high mobility in water and soil, high potential for long-range transport, and difficulty of remediation and water purification as well as moderate bioaccumulation in humans. The observed probable serious effects for human health and the environment are thyroid hormonal disturbances and reproductive toxicity seen in rodents, and effects on liver, kidney and haematological system in rats, hormonal disturbances and effects on reproduction in marine medaka fish and effects on expression of hormone receptors in tadpoles. Together, these elements lead to a very high potential for irreversible effects. | |
| Diisohexyl phthalate | 276-090-2 | 71850-09-4 | Toxic for reproduction (Article 57c) | 16/01/2020 | ||
| 2-methyl-1-(4-methylthiophenyl)-2-morpholinopropan-1-one | 400-600-6 | 71868-10-5 | Toxic for reproduction (Article 57c) | 16/01/2020 | ||
| 2-benzyl-2-dimethylamino-4'-morpholinobutyrophenone | 404-360-3 | 119313-12-1 | Toxic for reproduction (Article 57c) | 16/01/2020 | ||
| Tris(4-nonylphenyl, branched and linear) phosphite (TNPP) with ≥ 0.1% w/w of 4-nonylphenol, branched and linear (4-NP) | - | - | Endocrine disrupting properties (Article 57(f) - environment) | 16/07/2019 | ||
| tris(4-nonylphenyl, branched) phosphite, tris(nonylphenyl) phosphite | -, 247-759-6 | 26523-78-4 | Endocrine disrupting properties (Article 57(f) - environment) | 16/07/2019 | ||
| tris(4-nonylphenyl, branched) phosphite | 701-028-2 | - | Endocrine disrupting properties (Article 57(f) - environment) | 16/07/2019 | ||
| Phenol, 4-nonyl-, phosphite (3:1) | - | 3050-88-2 | Endocrine disrupting properties (Article 57(f) - environment) | 16/07/2019 | ||
| 4-tert-butylphenol | 202-679-0 | 98-54-4 | Endocrine disrupting properties (Article 57(f) - environment) | 16/07/2019 | ||
| 2-methoxyethyl acetate | 203-772-9 | 110-49-6 | Toxic for reproduction (Article 57c) | 16/07/2019 | ||
| 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propionic acid, its salts and its acyl halides | covering any of their individual isomers and combinations thereof | - | - | Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health)#Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment) | 16/07/2019 | The combined intrinsic properties justifying the inclusion for the Member State Committee as a substance for which there is scientific evidence of probable serious effects to human health and the environment which give rise to an equivalent level of concern are the following:\nPersistence, mobility, potential for long-range transport, observed adverse effects (at least the following probable effects for human health: effects on the liver, the kidney, and the haematological and immune systems and effects on development; at least the following probable effects for the environment: population relevant effects on birds and mammals); as well as low adsorption potential and high water solubility rendering the substance fully bioavailable for uptake via (drinking) water. Together, these elements lead to a very high potential for irreversible effects. |
| potassium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propionate | 266-578-3 | 67118-55-2 | Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health)#Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment) | 16/07/2019 | The combined intrinsic properties justifying the inclusion for the Member State Committee as a substance for which there is scientific evidence of probable serious effects to human health and the environment which give rise to an equivalent level of concern are the following:\nPersistence, mobility, potential for long-range transport, observed adverse effects (at least the following probable effects for human health: effects on the liver, the kidney, and the haematological and immune systems and effects on development; at least the following probable effects for the environment: population relevant effects on birds and mammals); as well as low adsorption potential and high water solubility rendering the substance fully bioavailable for uptake via (drinking) water. Together, these elements lead to a very high potential for irreversible effects. | |
| 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propionic acid | 236-236-8 | 13252-13-6 | Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health)#Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment) | 16/07/2019 | The combined intrinsic properties justifying the inclusion for the Member State Committee as a substance for which there is scientific evidence of probable serious effects to human health and the environment which give rise to an equivalent level of concern are the following:\nPersistence, mobility, potential for long-range transport, observed adverse effects (at least the following probable effects for human health: effects on the liver, the kidney, and the haematological and immune systems and effects on development; at least the following probable effects for the environment: population relevant effects on birds and mammals); as well as low adsorption potential and high water solubility rendering the substance fully bioavailable for uptake via (drinking) water. Together, these elements lead to a very high potential for irreversible effects. | |
| 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propionyl fluoride | 218-173-8 | 2062-98-8 | Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health)#Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment) | 16/07/2019 | The combined intrinsic properties justifying the inclusion for the Member State Committee as a substance for which there is scientific evidence of probable serious effects to human health and the environment which give rise to an equivalent level of concern are the following:\nPersistence, mobility, potential for long-range transport, observed adverse effects (at least the following probable effects for human health: effects on the liver, the kidney, and the haematological and immune systems and effects on development; at least the following probable effects for the environment: population relevant effects on birds and mammals); as well as low adsorption potential and high water solubility rendering the substance fully bioavailable for uptake via (drinking) water. Together, these elements lead to a very high potential for irreversible effects. | |
| ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoate | - | 62037-80-3 | Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health)#Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment) | 16/07/2019 | The combined intrinsic properties justifying the inclusion for the Member State Committee as a substance for which there is scientific evidence of probable serious effects to human health and the environment which give rise to an equivalent level of concern are the following:\nPersistence, mobility, potential for long-range transport, observed adverse effects (at least the following probable effects for human health: effects on the liver, the kidney, and the haematological and immune systems and effects on development; at least the following probable effects for the environment: population relevant effects on birds and mammals); as well as low adsorption potential and high water solubility rendering the substance fully bioavailable for uptake via (drinking) water. Together, these elements lead to a very high potential for irreversible effects. | |
| Pyrene | 204-927-3 | 129-00-0 | PBT (Article 57d)#vPvB (Article 57e) | 15/01/2019 | ||
| Phenanthrene | 201-581-5 | 85-01-8 | vPvB (Article 57e) | 15/01/2019 | ||
| Fluoranthene | 205-912-4 | 206-44-0 | PBT (Article 57d)#vPvB (Article 57e) | 15/01/2019 | ||
| Benzo[k]fluoranthene | 205-916-6 | 207-08-9 | Carcinogenic (Article 57a)#PBT (Article 57d)#vPvB (Article 57e) | 15/01/2019 | ||
| 2,2-bis(4'-hydroxyphenyl)-4-methylpentane | 401-720-1 | 6807-17-6 | Toxic for reproduction (Article 57c) | 15/01/2019 | ||
| 1,7,7-trimethyl-3-(phenylmethylene)bicyclo[2.2.1]heptan-2-one | 3-benzylidene camphor; 3-BC | 239-139-9 | 15087-24-8 | Endocrine disrupting properties (Article 57(f) - environment) | 15/01/2019 | |
| Terphenyl, hydrogenated | 262-967-7 | 61788-32-7 | vPvB (Article 57e) | 27/06/2018 | ||
| Octamethylcyclotetrasiloxane | D4 | 209-136-7 | 556-67-2 | PBT (Article 57d)#vPvB (Article 57e) | 27/06/2018 | |
| Lead | 231-100-4 | 7439-92-1 | Toxic for reproduction (Article 57c) | 27/06/2018 | ||
| Ethylenediamine | EDA | 203-468-6 | 107-15-3 | Respiratory sensitising properties (Article 57(f) - human health) | 27/06/2018 | |
| Dodecamethylcyclohexasiloxane | D6 | 208-762-8 | 540-97-6 | PBT (Article 57d)#vPvB (Article 57e) | 27/06/2018 | Dodecamethylcyclohexasiloxane (D6) meets the criteria of Article 57 (d) of Regulation (EC) 1907/2006 (REACH) as a substance which is persistent, bioaccumulative and toxic when it contains ≥ 0.1 % w/w octamethylcyclotetrasiloxane (D4) (EC No. 209-136-7). In addition to its intrinsic properties, it also meets the criteria of Article 57 (e) of Regulation (EC) 1907/2006 (REACH) as a substance which is very persistent and very bioaccumulative (vPvB) when it contains ≥ 0.1 % w/w decamethylcyclopentasiloxane (D5) (EC No. 208-764-9) or ≥ 0.1% w/w octamethylcyclotetrasiloxane (D4) (EC No. 209-136-7). |
| Disodium octaborate | 234-541-0 | 12008-41-2 | Toxic for reproduction (Article 57c) | 27/06/2018 | ||
| Dicyclohexyl phthalate | DCHP | 201-545-9 | 84-61-7 | Toxic for reproduction (Article 57c)#Endocrine disrupting properties (Article 57(f) - human health) | 27/06/2018 | |
| Decamethylcyclopentasiloxane | D5 | 208-764-9 | 541-02-6 | PBT (Article 57d)#vPvB (Article 57e) | 27/06/2018 | Decamethylcyclopentasiloxane (D5) meets the criteria of Article 57 (d) of Regulation (EC) 1907/2006 (REACH) as a substance which is persistent, bioaccumulative and toxic when it contains ≥ 0.1 % w/w octamethylcyclotetrasiloxane (D4) (EC No: 209-136-7). |
| Benzo[ghi]perylene | 205-883-8 | 191-24-2 | PBT (Article 57d)#vPvB (Article 57e) | 27/06/2018 | ||
| Benzene-1,2,4-tricarboxylic acid 1,2 anhydride | trimellitic anhydride; TMA | 209-008-0 | 552-30-7 | Respiratory sensitising properties (Article 57(f) - human health) | 27/06/2018 | |
| Reaction products of 1,3,4-thiadiazolidine-2,5-dithione, formaldehyde and 4-heptylphenol, branched and linear (RP-HP) | with ≥0.1% w/w 4-heptylphenol, branched and linear (4-HPbl) | - | - | Endocrine disrupting properties (Article 57(f) - environment) | 15/01/2018 | |
| Reaction product of 1,3,4-thiadiazolidine-2,5-dithione, formaldehyde and phenol, heptyl derivs. | 939-460-0 | - | Endocrine disrupting properties (Article 57(f) - environment) | 15/01/2018 | ||
| Formaldehyde, reaction products with branched and linear heptylphenol, carbon disulfide and hydrazine | 300-298-5 | 93925-00-9 | Endocrine disrupting properties (Article 57(f) - environment) | 15/01/2018 | ||
| Chrysene | 205-923-4 | 218-01-9 | Carcinogenic (Article 57a)#PBT (Article 57d)#vPvB (Article 57e) | 15/01/2018 | ||
| Cadmium nitrate | 233-710-6 | 10325-94-7 | Carcinogenic (Article 57a)#Mutagenic (Article 57b)#Specific target organ toxicity after repeated exposure (Article 57(f) - human health) | 15/01/2018 | ||
| Cadmium hydroxide | 244-168-5 | 21041-95-2 | Carcinogenic (Article 57a)#Mutagenic (Article 57b)#Specific target organ toxicity after repeated exposure (Article 57(f) - human health) | 15/01/2018 | ||
| Cadmium carbonate | 208-168-9 | 513-78-0 | Carcinogenic (Article 57a)#Mutagenic (Article 57b)#Specific target organ toxicity after repeated exposure (Article 57(f) - human health) | 15/01/2018 | ||
| Benz[a]anthracene | 200-280-6 | 56-55-3 | Carcinogenic (Article 57a)#PBT (Article 57d)#vPvB (Article 57e) | 15/01/2018 | ||
| 1,6,7,8,9,14,15,16,17,17,18,18-Dodecachloropentacyclo[12.2.1.16,9.02,13.05,10]octadeca-7,15-diene (“Dechlorane Plus”™) | covering any of its individual anti- and syn-isomers or any combination thereof | - | - | vPvB (Article 57e) | 15/01/2018 | |
| (1S,2S,5R,6R,9S,10S,13R,14R)-1,6,7,8,9,14,15,16,17,17,18,18-Dodecachloropentacyclo[12.2.1.1⁶,⁹.0²,¹³.0⁵,¹⁰]octadeca-7,15-diene | - | 135821-03-3 | vPvB (Article 57e) | 15/01/2018 | ||
| (1S,2S,5S,6S,9R,10R,13R,14R)-1,6,7,8,9,14,15,16,17,17,18,18-Dodecachloropentacyclo[12.2.1.1⁶,⁹.0²,¹³.0⁵,¹⁰]octadeca-7,15-diene | - | 135821-74-8 | vPvB (Article 57e) | 15/01/2018 | ||
| 1,6,7,8,9,14,15,16,17,17,18,18-dodecachloropentacyclo[12.2.1.16,9.02,13.05,10]octadeca-7,15-diene | 236-948-9 | 13560-89-9 | vPvB (Article 57e) | 15/01/2018 | ||
| rel-(1R,4S,4aS,6aS,7S,10R,10aR,12aR)-1,2,3,4,7,8,9,10,13,13,14,14-dodecachloro-1,4,4a,5,6,6a,7,10,10a,11,12,12a-dodecahydro-1,4:7,10-dimethanodibenzo[a,e]cyclooctene | - | - | vPvB (Article 57e) | 15/01/2018 | ||
| rel-(1R,4S,4aS,6aR,7R,10S,10aS,12aR)-1,2,3,4,7,8,9,10,13,13,14,14-dodecachloro-1,4,4a,5,6,6a,7,10,10a,11,12,12a-dodecahydro-1,4:7,10-dimethanodibenzo[a,e]cyclooctene | - | - | vPvB (Article 57e) | 15/01/2018 | ||
| Perfluorohexane-1-sulphonic acid and its salts | PFHxS | - | - | vPvB (Article 57e) | 07/07/2017 | |
| ammonium perfluorohexane-1-sulphonate | 269-511-6 | 68259-08-5 | vPvB (Article 57e) | 07/07/2017 | ||
| perfluorohexane-1-sulphonic acid | 206-587-1 | 355-46-4 | vPvB (Article 57e) | 07/07/2017 | ||
| potassium perfluorohexane-1-sulphonate | 223-393-2 | 3871-99-6 | vPvB (Article 57e) | 07/07/2017 | ||
| tridecafluorohexanesulphonic acid, compound with 2,2'-iminodiethanol (1:1) | 274-462-9 | 70225-16-0 | vPvB (Article 57e) | 07/07/2017 | ||
| p-(1,1-dimethylpropyl)phenol | 201-280-9 | 80-46-6 | Endocrine disrupting properties (Article 57(f) - environment) | 12/01/2017 | ||
| Nonadecafluorodecanoic acid (PFDA) and its sodium and ammonium salts | - | - | Toxic for reproduction (Article 57c)#PBT (Article 57d) | 12/01/2017 | ||
| Decanoic acid, nonadecafluoro-, sodium salt | - | 3830-45-3 | Toxic for reproduction (Article 57c)#PBT (Article 57d) | 12/01/2017 | ||
| Ammonium nonadecafluorodecanoate | 221-470-5 | 3108-42-7 | Toxic for reproduction (Article 57c)#PBT (Article 57d) | 12/01/2017 | ||
| Nonadecafluorodecanoic acid | 206-400-3 | 335-76-2 | Toxic for reproduction (Article 57c)#PBT (Article 57d) | 12/01/2017 | ||
| 4-heptylphenol, branched and linear | substances with a linear and/or branched alkyl chain with a carbon number of 7 covalently bound predominantly in position 4 to phenol, covering also UVCB- and well-defined substances which include any of the individual isomers or a combination thereof | - | - | Endocrine disrupting properties (Article 57(f) - environment) | 12/01/2017 | |
| 4-heptylphenol | 217-862-0 | 1987-50-4 | Endocrine disrupting properties (Article 57(f) - environment) | 12/01/2017 | ||
| Phenol, heptyl derivs. | 276-743-1 | 72624-02-3 | Endocrine disrupting properties (Article 57(f) - environment) | 12/01/2017 | ||
| 4,4'-isopropylidenediphenol | Bisphenol A; BPA | 201-245-8 | 80-05-7 | Toxic for reproduction (Article 57c)#Endocrine disrupting properties (Article 57(f) - environment)#Endocrine disrupting properties (Article 57(f) - human health) | 12/01/2017 | |
| Benzo[def]chrysene (Benzo[a]pyrene) | 200-028-5 | 50-32-8 | Carcinogenic (Article 57a)#Mutagenic (Article 57b)#Toxic for reproduction (Article 57c)#PBT (Article 57d)#vPvB (Article 57e) | 20/06/2016 | ||
| Perfluorononan-1-oic-acid and its sodium and ammonium salts | - | - | Toxic for reproduction (Article 57c)#PBT (Article 57d) | 17/12/2015 | ||
| Ammonium salts of perfluorononan-1-oic-acid | - | -, 4149-60-4 | Toxic for reproduction (Article 57c)#PBT (Article 57d) | 17/12/2015 | ||
| Perfluorononan-1-oic-acid | 206-801-3 | 375-95-1 | Toxic for reproduction (Article 57c)#PBT (Article 57d) | 17/12/2015 | ||
| Sodium salts of perfluorononan-1-oic-acid | - | -, 21049-39-8 | Toxic for reproduction (Article 57c)#PBT (Article 57d) | 17/12/2015 | ||
| Nitrobenzene | 202-716-0 | 98-95-3 | Toxic for reproduction (Article 57c) | 17/12/2015 | ||
| 2-(2H-benzotriazol-2-yl)-4-(tert-butyl)-6-(sec-butyl)phenol (UV-350) | 253-037-1 | 36437-37-3 | vPvB (Article 57e) | 17/12/2015 | ||
| 2,4-di-tert-butyl-6-(5-chlorobenzotriazol-2-yl)phenol (UV-327) | 223-383-8 | 3864-99-1 | vPvB (Article 57e) | 17/12/2015 | ||
| 1,3-propanesultone | 214-317-9 | 1120-71-4 | Carcinogenic (Article 57a) | 17/12/2015 | ||
| 5-sec-butyl-2-(2,4-dimethylcyclohex-3-en-1-yl)-5-methyl-1,3-dioxane [1], 5-sec-butyl-2-(4,6-dimethylcyclohex-3-en-1-yl)-5-methyl-1,3-dioxane [2] | covering any of the individual stereoisomers of [1] and [2] or any combination thereof | - | - | vPvB (Article 57e) | 15/06/2015 | |
| Reaction mass of 5-sec-butyl-2-(2,4-dimethylcyclohex-3-en-1-yl)-5-methyl-1,3-dioxane and 5-sec-butyl-2-(4,6-dimethylcyclohex-3-en-1-yl)-5-methyl-1,3-dioxane | 413-720-9 | 117933-89-8 | vPvB (Article 57e) | 15/06/2015 | ||
| 2-(2,4-Dimethylcyclohex-3-ene-1-yl)-5-methyl-(1-methylpropyl)-1,3-dioxane | 601-499-3 | 117933-89-8 | vPvB (Article 57e) | 15/06/2015 | ||
| Reaction mass of 5-[(2R)-butan-2-yl]-2-[(1R,2R)-2,4-dimethylcyclohex-3-en-1-yl]-5-methyl-1,3-dioxane and 5-[(2R)-butan-2-yl]-2-[(1R,2S)-2,4-dimethylcyclohex-3-en-1-yl]-5-methyl-1,3-dioxane and 5-[(2R)-butan-2-yl]-2-[(1S,2R)-2,4-dimethylcyclohex-3-en-1-yl]-5-methyl-1,3-dioxane and 5-[(2R)-butan-2-yl]-2-[(1S,2S)-2,4-dimethylcyclohex-3-en-1-yl]-5-methyl-1,3-dioxane and 5-[(2S)-butan-2-yl]-2-[(1S,2R)-2,4-dimethylcyclohex-3-en-1-yl]-5-methyl-1,3-dioxane and 5-[(2S)-butan-2-yl]-2-[(1S,2S)-2,4-dimethylcyclohex-3-en-1-yl]-5-methyl-1,3-dioxane | 700-927-7 | - | vPvB (Article 57e) | 15/06/2015 | ||
| 5-sec-butyl-2-(2,4-dimethylcyclohex-3-en-1-yl)-5-methyl-1,3-dioxane | - | - | vPvB (Article 57e) | 15/06/2015 | ||
| 5-sec-butyl-2-(4,6-dimethylcyclohex-3-en-1-yl)-5-methyl-1,3-dioxane | - | - | vPvB (Article 57e) | 15/06/2015 | ||
| 1,2-benzenedicarboxylic acid, di-C6-10-alkyl esters or mixed decyl and hexyl and octyl diesters | with ≥ 0.3% of dihexyl phthalate (EC No. 201-559-5) | - | - | Toxic for reproduction (Article 57c) | 15/06/2015 | |
| 1,2-Benzenedicarboxylic acid, mixed decyl and hexyl and octyl diesters | 272-013-1 | 68648-93-1 | Toxic for reproduction (Article 57c) | 15/06/2015 | ||
| 1,2-Benzenedicarboxylic acid, di-C6-10-alkyl esters | 271-094-0 | 68515-51-5 | Toxic for reproduction (Article 57c) | 15/06/2015 | ||
| Reaction mass of 2-ethylhexyl 10-ethyl-4,4-dioctyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate and 2-ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-octyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate (reaction mass of DOTE and MOTE) | - | - | Toxic for reproduction (Article 57c) | 17/12/2014 | ||
| Cadmium sulphate | 233-331-6 | 10124-36-4, 31119-53-6 | Carcinogenic (Article 57a)#Mutagenic (Article 57b)#Toxic for reproduction (Article 57c)#Specific target organ toxicity after repeated exposure (Article 57(f) - human health) | 17/12/2014 | ||
| Cadmium fluoride | 232-222-0 | 7790-79-6 | Carcinogenic (Article 57a)#Mutagenic (Article 57b)#Toxic for reproduction (Article 57c)#Specific target organ toxicity after repeated exposure (Article 57(f) - human health) | 17/12/2014 | ||
| 2-ethylhexyl 10-ethyl-4,4-dioctyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate (DOTE) | 239-622-4 | 15571-58-1 | Toxic for reproduction (Article 57c) | 17/12/2014 | ||
| 2-benzotriazol-2-yl-4,6-di-tert-butylphenol (UV-320) | 223-346-6 | 3846-71-7 | PBT (Article 57d)#vPvB (Article 57e) | 17/12/2014 | ||
| 2-(2H-benzotriazol-2-yl)-4,6-ditertpentylphenol (UV-328) | 247-384-8 | 25973-55-1 | PBT (Article 57d)#vPvB (Article 57e) | 17/12/2014 | ||
| Sodium peroxometaborate | 231-556-4 | 7632-04-4 | Toxic for reproduction (Article 57c) | 16/06/2014 | ||
| Sodium perborate, perboric acid, sodium salt | - | - | Toxic for reproduction (Article 57c) | 16/06/2014 | ||
| Perboric acid, sodium salt | 234-390-0 | 11138-47-9 | Toxic for reproduction (Article 57c) | 16/06/2014 | ||
| Sodium perborate | 239-172-9 | 15120-21-5 | Toxic for reproduction (Article 57c) | 16/06/2014 | ||
| Cadmium chloride | 233-296-7 | 10108-64-2 | Carcinogenic (Article 57a)#Mutagenic (Article 57b)#Toxic for reproduction (Article 57c)#Specific target organ toxicity after repeated exposure (Article 57(f) - human health) | 16/06/2014 | ||
| 1,2-Benzenedicarboxylic acid, dihexyl ester, branched and linear | 271-093-5 | 68515-50-4 | Toxic for reproduction (Article 57c) | 16/06/2014 | ||
| Trixylyl phosphate | 246-677-8 | 25155-23-1 | Toxic for reproduction (Article 57c) | 16/12/2013 | ||
| Lead di(acetate) | 206-104-4 | 301-04-2 | Toxic for reproduction (Article 57c) | 16/12/2013 | ||
| Imidazolidine-2-thione (2-imidazoline-2-thiol) | 202-506-9 | 96-45-7 | Toxic for reproduction (Article 57c) | 16/12/2013 | ||
| Disodium 4-amino-3-[[4'-[(2,4-diaminophenyl)azo][1,1'-biphenyl]-4-yl]azo] -5-hydroxy-6-(phenylazo)naphthalene-2,7-disulphonate (C.I. Direct Black 38) | 217-710-3 | 1937-37-7 | Carcinogenic (Article 57a) | 16/12/2013 | ||
| Disodium 3,3'-[[1,1'-biphenyl]-4,4'-diylbis(azo)]bis(4-aminonaphthalene-1-sulphonate) (C.I. Direct Red 28) | 209-358-4 | 573-58-0 | Carcinogenic (Article 57a) | 16/12/2013 | ||
| Dihexyl phthalate | 201-559-5 | 84-75-3 | Toxic for reproduction (Article 57c) | 16/12/2013 | ||
| Cadmium sulphide | 215-147-8 | 1306-23-6 | Carcinogenic (Article 57a)#Specific target organ toxicity after repeated exposure (Article 57(f) - human health) | 16/12/2013 | ||
| Pentadecafluorooctanoic acid (PFOA) | 206-397-9 | 335-67-1 | Toxic for reproduction (Article 57c)#PBT (Article 57d) | 20/06/2013 | ||
| Dipentyl phthalate (DPP) | 205-017-9 | 131-18-0 | Toxic for reproduction (Article 57c) | 20/06/2013 | ||
| Cadmium oxide | 215-146-2 | 1306-19-0 | Carcinogenic (Article 57a)#Specific target organ toxicity after repeated exposure (Article 57(f) - human health) | 20/06/2013 | ||
| Cadmium | 231-152-8 | 7440-43-9 | Carcinogenic (Article 57a)#Specific target organ toxicity after repeated exposure (Article 57(f) - human health) | 20/06/2013 | ||
| Ammonium pentadecafluorooctanoate (APFO) | 223-320-4 | 3825-26-1 | Toxic for reproduction (Article 57c)#PBT (Article 57d) | 20/06/2013 | ||
| 4-Nonylphenol, branched and linear, ethoxylated | substances with a linear and/or branched alkyl chain with a carbon number of 9 covalently bound in position 4 to phenol, ethoxylated covering UVCB- and well-defined substances, polymers and homologues, which include any of the individual isomers and/or combinations thereof | - | - | Endocrine disrupting properties (Article 57(f) - environment) | 20/06/2013 | |
| 2-[2-(4-nonylphenoxy)ethoxy]ethanol | 243-816-4 | 20427-84-3 | Endocrine disrupting properties (Article 57(f) - environment) | 20/06/2013 | ||
| 2-[2-[2-[2-(4-nonylphenoxy)ethoxy]ethoxy]ethoxy]ethanol | 230-770-5 | 7311-27-5 | Endocrine disrupting properties (Article 57(f) - environment) | 20/06/2013 | ||
| Nonylphenol, ethoxylated (10-EO) (9016-45-9) | 931-755-2 | - | Endocrine disrupting properties (Article 57(f) - environment) | 20/06/2013 | ||
| Nonylphenol, ethoxylated (8-EO) (9016-45-9) | 931-754-7 | - | Endocrine disrupting properties (Article 57(f) - environment) | 20/06/2013 | ||
| Nonylphenol, ethoxylated (6,5-EO) (9016-45-9) | 931-753-1 | - | Endocrine disrupting properties (Article 57(f) - environment) | 20/06/2013 | ||
| 26-(4-Nonylphenoxy)-3,6,9,12,15,18,21,24- octaoxahexacosan -1-ol | - | 14409-72-4 | Endocrine disrupting properties (Article 57(f) - environment) | 20/06/2013 | ||
| Nonylphenol, branched, ethoxylated | 1 - 2.5 moles ethoxylated | 500-209-1 | 68412-54-4 | Endocrine disrupting properties (Article 57(f) - environment) | 20/06/2013 | |
| 4-Nonylphenol, ethoxylated | 1 - 2.5 moles ethoxylated | 500-045-0 | 26027-38-3 | Endocrine disrupting properties (Article 57(f) - environment) | 20/06/2013 | |
| Nonylphenol, ethoxylated | 500-024-6 | 9016-45-9 | Endocrine disrupting properties (Article 57(f) - environment) | 20/06/2013 | ||
| Nonylphenol, ethoxylated (15-EO) (9016-45-9) | 931-756-8 | - | Endocrine disrupting properties (Article 57(f) - environment) | 20/06/2013 | ||
| Nonylphenol, branched, ethoxylated (CAS# 68412-54-4) | 932-688-1 | - | Endocrine disrupting properties (Article 57(f) - environment) | 20/06/2013 | ||
| 20-(4-nonylphenoxy)-3,6,9,12,15,18-hexaoxaicosan-1-ol | 248-743-1 | 27942-27-4 | Endocrine disrupting properties (Article 57(f) - environment) | 20/06/2013 | ||
| Isononylphenol, ethoxylated | 609-346-2 | 37205-87-1 | Endocrine disrupting properties (Article 57(f) - environment) | 20/06/2013 | ||
| Nonylphenol, ethoxylated (EO = 10) | 939-993-9 | - | Endocrine disrupting properties (Article 57(f) - environment) | 20/06/2013 | ||
| Nonylphenol, ethoxylated (EO = 4) | 939-975-0 | - | Endocrine disrupting properties (Article 57(f) - environment) | 20/06/2013 | ||
| Nonylphenol, ethoxylated (polymer) | 938-618-6 | - | Endocrine disrupting properties (Article 57(f) - environment) | 20/06/2013 | ||
| 26-(nonylphenoxy)-3,6,9,12,15,18,21,24-octaoxahexacosan-1-ol | 247-816-5 | 26571-11-9 | Endocrine disrupting properties (Article 57(f) - environment) | 20/06/2013 | ||
| 2-[4-(3,6-dimethylheptan-3-yl)phenoxy]ethanol | 687-832-3 | 1119449-37-4 | Endocrine disrupting properties (Article 57(f) - environment) | 20/06/2013 | ||
| Nonylphenolpolyglycolether | 932-998-7 | - | Endocrine disrupting properties (Article 57(f) - environment) | 20/06/2013 | ||
| Poly(oxy-1,2-ethanediyl), a-(nonylphenyl)-w-hydroxy- (CAS 9016-45-9) | 931-562-3 | 9016-45-9 | Endocrine disrupting properties (Article 57(f) - environment) | 20/06/2013 | ||
| 4-Nonylphenol, branched, ethoxylated | 1 - 2.5 moles ethoxylated | 500-315-8 | 127087-87-0 | Endocrine disrupting properties (Article 57(f) - environment) | 20/06/2013 | |
| 2-{2-[4-(3,6-dimethylheptan-3-yl)phenoxy]ethoxy}ethanol | 687-833-9 | 1119449-38-5 | Endocrine disrupting properties (Article 57(f) - environment) | 20/06/2013 | ||
| Trilead dioxide phosphonate | 235-252-2 | 12141-20-7 | Toxic for reproduction (Article 57c) | 19/12/2012 | ||
| Trilead bis(carbonate) dihydroxide | 215-290-6 | 1319-46-6 | Toxic for reproduction (Article 57c) | 19/12/2012 | ||
| Tricosafluorododecanoic acid | 206-203-2 | 307-55-1 | vPvB (Article 57e) | 19/12/2012 | ||
| Tetralead trioxide sulphate | 235-380-9 | 12202-17-4 | Toxic for reproduction (Article 57c) | 19/12/2012 | ||
| Tetraethyllead | 201-075-4 | 78-00-2 | Toxic for reproduction (Article 57c) | 19/12/2012 | ||
| Sulfurous acid, lead salt, dibasic | 263-467-1 | 62229-08-7 | Toxic for reproduction (Article 57c) | 19/12/2012 | ||
| Silicic acid, lead salt | 234-363-3 | 11120-22-2 | Toxic for reproduction (Article 57c) | 19/12/2012 | ||
| Silicic acid (H2Si2O5), barium salt (1:1), lead-doped | with lead (Pb) content above the applicable generic concentration limit for ’toxicity for reproduction’ Repr. 1A (CLP) or category 1 (DSD),the substance is a member of the group entry of lead compounds, with index number 082-001-00-6 in Regulation (EC) No 1272/2008 | 272-271-5 | 68784-75-8 | Toxic for reproduction (Article 57c) | 19/12/2012 | |
| Pyrochlore, antimony lead yellow | - | 232-382-1 | 8012-00-8 | Toxic for reproduction (Article 57c) | 19/12/2012 | |
| Pentalead tetraoxide sulphate | 235-067-7 | 12065-90-6 | Toxic for reproduction (Article 57c) | 19/12/2012 | ||
| Pentacosafluorotridecanoic acid | 276-745-2 | 72629-94-8 | vPvB (Article 57e) | 19/12/2012 | ||
| Orange lead (lead tetroxide) | 215-235-6 | 1314-41-6 | Toxic for reproduction (Article 57c) | 19/12/2012 | ||
| o-toluidine | 202-429-0 | 95-53-4 | Carcinogenic (Article 57a) | 19/12/2012 | ||
| o-aminoazotoluene | 202-591-2 | 97-56-3 | Carcinogenic (Article 57a) | 19/12/2012 | ||
| n-pentyl-isopentylphthalate | 933-378-9 | 776297-69-9 | Toxic for reproduction (Article 57c) | 19/12/2012 | ||
| N-methylacetamide | 201-182-6 | 79-16-3 | Toxic for reproduction (Article 57c) | 19/12/2012 | ||
| N,N-dimethylformamide | 200-679-5 | 68-12-2 | Toxic for reproduction (Article 57c) | 19/12/2012 | ||
| Methyloxirane (Propylene oxide) | 200-879-2 | 75-56-9 | Carcinogenic (Article 57a)#Mutagenic (Article 57b) | 19/12/2012 | ||
| Methoxyacetic acid | 210-894-6 | 625-45-6 | Toxic for reproduction (Article 57c) | 19/12/2012 | ||
| Lead titanium zirconium oxide | 235-727-4 | 12626-81-2 | Toxic for reproduction (Article 57c) | 19/12/2012 | ||
| Lead titanium trioxide | 235-038-9 | 12060-00-3 | Toxic for reproduction (Article 57c) | 19/12/2012 | ||
| Lead oxide sulfate | 234-853-7 | 12036-76-9 | Toxic for reproduction (Article 57c) | 19/12/2012 | ||
| Lead monoxide (lead oxide) | 215-267-0 | 1317-36-8 | Toxic for reproduction (Article 57c) | 19/12/2012 | ||
| Lead dinitrate | 233-245-9 | 10099-74-8 | Toxic for reproduction (Article 57c) | 19/12/2012 | ||
| Lead cyanamidate | 244-073-9 | 20837-86-9 | Toxic for reproduction (Article 57c) | 19/12/2012 | ||
| Lead bis(tetrafluoroborate) | 237-486-0 | 13814-96-5 | Toxic for reproduction (Article 57c) | 19/12/2012 | ||
| Hexahydromethylphthalic anhydride | including cis- and trans- stereo isomeric forms and all possible combinations of the isomers | - | - | Respiratory sensitising properties (Article 57(f) - human health) | 19/12/2012 | |
| Hexahydromethylphthalic anhydride | 247-094-1 | 25550-51-0 | Respiratory sensitising properties (Article 57(f) - human health) | 19/12/2012 | ||
| Hexahydro-4-methylphthalic anhydride | 243-072-0 | 19438-60-9 | Respiratory sensitising properties (Article 57(f) - human health) | 19/12/2012 | ||
| Hexahydro-3-methylphthalic anhydride | 260-566-1 | 57110-29-9 | Respiratory sensitising properties (Article 57(f) - human health) | 19/12/2012 | ||
| Hexahydro-1-methylphthalic anhydride | 256-356-4 | 48122-14-1 | Respiratory sensitising properties (Article 57(f) - human health) | 19/12/2012 | ||
| Heptacosafluorotetradecanoic acid | 206-803-4 | 376-06-7 | vPvB (Article 57e) | 19/12/2012 | ||
| Henicosafluoroundecanoic acid | 218-165-4 | 2058-94-8 | vPvB (Article 57e) | 19/12/2012 | ||
| Furan | 203-727-3 | 110-00-9 | Carcinogenic (Article 57a) | 19/12/2012 | ||
| Fatty acids, C16-18, lead salts | 292-966-7 | 91031-62-8 | Toxic for reproduction (Article 57c) | 19/12/2012 | ||
| Dioxobis(stearato)trilead | 235-702-8 | 12578-12-0 | Toxic for reproduction (Article 57c) | 19/12/2012 | ||
| Dinoseb (6-sec-butyl-2,4-dinitrophenol) | 201-861-7 | 88-85-7 | Toxic for reproduction (Article 57c) | 19/12/2012 | ||
| Dimethyl sulphate | 201-058-1 | 77-78-1 | Carcinogenic (Article 57a) | 19/12/2012 | ||
| Diisopentyl phthalate | 210-088-4 | 605-50-5 | Toxic for reproduction (Article 57c) | 19/12/2012 | ||
| Diethyl sulphate | 200-589-6 | 64-67-5 | Carcinogenic (Article 57a)#Mutagenic (Article 57b) | 19/12/2012 | ||
| Dibutyltin dichloride (DBTC) | 211-670-0 | 683-18-1 | Toxic for reproduction (Article 57c) | 19/12/2012 | ||
| Diazene-1,2-dicarboxamide (C,C'-azodi(formamide)) (ADCA) | 204-650-8 | 123-77-3 | Respiratory sensitising properties (Article 57(f) - human health) | 19/12/2012 | ||
| Cyclohexane-1,2-dicarboxylic anhydride | all possible combinations of the cis- and trans-isomers | - | - | Respiratory sensitising properties (Article 57(f) - human health) | 19/12/2012 | |
| Cyclohexane-1,2-dicarboxylic anhydride | 201-604-9 | 85-42-7 | Respiratory sensitising properties (Article 57(f) - human health) | 19/12/2012 | ||
| trans-cyclohexane-1,2-dicarboxylic anhydride | 238-009-9 | 14166-21-3 | Respiratory sensitising properties (Article 57(f) - human health) | 19/12/2012 | ||
| cis-cyclohexane-1,2-dicarboxylic anhydride | 236-086-3 | 13149-00-3 | Respiratory sensitising properties (Article 57(f) - human health) | 19/12/2012 | ||
| Bis(pentabromophenyl) ether (decabromodiphenyl ether) (DecaBDE) | 214-604-9 | 1163-19-5 | PBT (Article 57d)#vPvB (Article 57e) | 19/12/2012 | ||
| Biphenyl-4-ylamine | 202-177-1 | 92-67-1 | Carcinogenic (Article 57a) | 19/12/2012 | ||
| Acetic acid, lead salt, basic | 257-175-3 | 51404-69-4 | Toxic for reproduction (Article 57c) | 19/12/2012 | ||
| [Phthalato(2-)]dioxotrilead | 273-688-5 | 69011-06-9 | Toxic for reproduction (Article 57c) | 19/12/2012 | ||
| 6-methoxy-m-toluidine (p-cresidine) | 204-419-1 | 120-71-8 | Carcinogenic (Article 57a) | 19/12/2012 | ||
| 4-Nonylphenol, branched and linear | substances with a linear and/or branched alkyl chain with a carbon number of 9 covalently bound in position 4 to phenol, covering also UVCB- and well-defined substances which include any of the individual isomers or a combination thereof | - | - | Endocrine disrupting properties (Article 57(f) - environment) | 19/12/2012 | |
| 4-(1-Ethyl-1,3-dimethylpentyl)phenol | - | 186825-36-5 | Endocrine disrupting properties (Article 57(f) - environment) | 19/12/2012 | ||
| Phenol, 4-nonyl-, branched | 284-325-5 | 84852-15-3 | Endocrine disrupting properties (Article 57(f) - environment) | 19/12/2012 | ||
| p-nonylphenol | 203-199-4 | 104-40-5 | Endocrine disrupting properties (Article 57(f) - environment) | 19/12/2012 | ||
| 4-(1-Ethyl-1,4-dimethylpentyl)phenol | - | 142731-63-3 | Endocrine disrupting properties (Article 57(f) - environment) | 19/12/2012 | ||
| p-(1-methyloctyl)phenol | 241-427-4 | 17404-66-9 | Endocrine disrupting properties (Article 57(f) - environment) | 19/12/2012 | ||
| p-isononylphenol | 247-770-6 | 26543-97-5 | Endocrine disrupting properties (Article 57(f) - environment) | 19/12/2012 | ||
| p-(1,1-dimethylheptyl)phenol | 250-339-5 | 30784-30-6 | Endocrine disrupting properties (Article 57(f) - environment) | 19/12/2012 | ||
| 4-(1-ethyl-1-methylhexyl)phenol | 257-907-1 | 52427-13-1 | Endocrine disrupting properties (Article 57(f) - environment) | 19/12/2012 | ||
| 4-(3-ethylheptan-2-yl)phenol | 635-696-0 | 186825-39-8 | Endocrine disrupting properties (Article 57(f) - environment) | 19/12/2012 | ||
| Isononylphenol | 234-284-4 | 11066-49-2 | Endocrine disrupting properties (Article 57(f) - environment) | 19/12/2012 | ||
| Phenol, nonyl-, branched | 291-844-0 | 90481-04-2 | Endocrine disrupting properties (Article 57(f) - environment) | 19/12/2012 | ||
| 4-(1,1,5-Trimethylhexyl)phenol | 635-388-6 | 521947-27-3 | Endocrine disrupting properties (Article 57(f) - environment) | 19/12/2012 | ||
| Nonylphenol | 246-672-0 | 25154-52-3 | Endocrine disrupting properties (Article 57(f) - environment) | 19/12/2012 | ||
| 4-methyl-m-phenylenediamine (toluene-2,4-diamine) | 202-453-1 | 95-80-7 | Carcinogenic (Article 57a) | 19/12/2012 | ||
| 4-aminoazobenzene | 200-453-6 | 60-09-3 | Carcinogenic (Article 57a) | 19/12/2012 | ||
| 4-(1,1,3,3-tetramethylbutyl)phenol, ethoxylated | covering well-defined substances and UVCB substances, polymers and homologues | - | - | Endocrine disrupting properties (Article 57(f) - environment) | 19/12/2012 | |
| Polyethylene glycol mono(tert-octylph-enyl) ether9036-19-5 | - | 9036-19-5 | Endocrine disrupting properties (Article 57(f) - environment) | 19/12/2012 | ||
| 2-[[]4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethanol | 618-344-0 | 9002-93-1 | Endocrine disrupting properties (Article 57(f) - environment) | 19/12/2012 | ||
| 20-[4-(1,1,3,3-tetramethylbutyl)phenoxy]-3,6,9,12,15,18-hexaoxaicosan-1-ol | 219-682-8 | 2497-59-8 | Endocrine disrupting properties (Article 57(f) - environment) | 19/12/2012 | ||
| 2-[4-(1,1,3,3-tetramethylbutyl)phenoxy]ethanol | - | 2315-67-5 | Endocrine disrupting properties (Article 57(f) - environment) | 19/12/2012 | ||
| 2-[2-[4-(1,1,3,3-tetramethylbutyl)phenoxy]ethoxy]ethanol, 2-{2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy}ethanol | -, 621-341-7 | 2315-61-9 | Endocrine disrupting properties (Article 57(f) - environment) | 19/12/2012 | ||
| 4,4'-oxydianiline and its salts | - | - | Carcinogenic (Article 57a)#Mutagenic (Article 57b) | 19/12/2012 | ||
| 4,4'-oxydianiline | 202-977-0 | 101-80-4 | Carcinogenic (Article 57a)#Mutagenic (Article 57b) | 19/12/2012 | ||
| 4,4'-methylenedi-o-toluidine | 212-658-8 | 838-88-0 | Carcinogenic (Article 57a) | 19/12/2012 | ||
| 3-ethyl-2-methyl-2-(3-methylbutyl)-1,3-oxazolidine | 421-150-7 | 143860-04-2 | Toxic for reproduction (Article 57c) | 19/12/2012 | ||
| 1-bromopropane (n-propyl bromide) | 203-445-0 | 106-94-5 | Toxic for reproduction (Article 57c) | 19/12/2012 | ||
| 1,2-diethoxyethane | 211-076-1 | 629-14-1 | Toxic for reproduction (Article 57c) | 19/12/2012 | ||
| 1,2-Benzenedicarboxylic acid, dipentyl ester, branched and linear | 284-032-2 | 84777-06-0 | Toxic for reproduction (Article 57c) | 19/12/2012 | ||
| α,α-Bis[4-(dimethylamino)phenyl]-4 (phenylamino)naphthalene-1-methanol (C.I. Solvent Blue 4) | with ≥ 0.1% of Michler's ketone (EC No. 202-027-5) or Michler's base (EC No. 202-959-2) | 229-851-8 | 6786-83-0 | Carcinogenic (Article 57a) | 18/06/2012 | |
| N,N,N',N'-tetramethyl-4,4'-methylenedianiline (Michler’s base) | 202-959-2 | 101-61-1 | Carcinogenic (Article 57a) | 18/06/2012 | ||
| Lead(II) bis(methanesulfonate) | - | 401-750-5 | 17570-76-2 | Toxic for reproduction (Article 57c) | 18/06/2012 | |
| Formamide | 200-842-0 | 75-12-7 | Toxic for reproduction (Article 57c) | 18/06/2012 | ||
| Diboron trioxide | 215-125-8 | 1303-86-2 | Toxic for reproduction (Article 57c) | 18/06/2012 | ||
| [4-[[4-anilino-1-naphthyl][4-(dimethylamino)phenyl]methylene]cyclohexa-2,5-dien-1-ylidene] dimethylammonium chloride (C.I. Basic Blue 26) | with ≥ 0.1% of Michler's ketone (EC No. 202-027-5) or Michler's base (EC No. 202-959-2) | 219-943-6 | 2580-56-5 | Carcinogenic (Article 57a) | 18/06/2012 | |
| [4-[4,4'-bis(dimethylamino) benzhydrylidene]cyclohexa-2,5-dien-1-ylidene]dimethylammonium chloride (C.I. Basic Violet 3) | with ≥ 0.1% of Michler's ketone (EC No. 202-027-5) or Michler's base (EC No. 202-959-2) | 208-953-6 | 548-62-9 | Carcinogenic (Article 57a) | 18/06/2012 | |
| 4,4'-bis(dimethylamino)benzophenone (Michler’s ketone) | 202-027-5 | 90-94-8 | Carcinogenic (Article 57a) | 18/06/2012 | ||
| 4,4'-bis(dimethylamino)-4''-(methylamino)trityl alcohol | with ≥ 0.1% of Michler's ketone (EC No. 202-027-5) or Michler's base (EC No. 202-959-2) | 209-218-2 | 561-41-1 | Carcinogenic (Article 57a) | 18/06/2012 | |
| 1,3,5-tris[(2S and 2R)-2,3-epoxypropyl]-1,3,5-triazine-2,4,6-(1H,3H,5H)-trione (β-TGIC) | - | 423-400-0 | 59653-74-6 | Mutagenic (Article 57b) | 18/06/2012 | |
| 1,3,5-Tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione (TGIC) | 219-514-3 | 2451-62-9 | Mutagenic (Article 57b) | 18/06/2012 | ||
| 1,2-bis(2-methoxyethoxy)ethane (TEGDME; triglyme) | 203-977-3 | 112-49-2 | Toxic for reproduction (Article 57c) | 18/06/2012 | ||
| 1, 2-dimethoxyethane; ethylene glycol dimethyl ether (EGDME) | 203-794-9 | 110-71-4 | Toxic for reproduction (Article 57c) | 18/06/2012 | ||
| Zirconia Aluminosilicate Refractory Ceramic Fibres | are fibres covered by index number 650-017-00-8 in Annex VI, part 3, table 3.1 of Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, and fulfil the three following conditions: a) oxides of aluminium, silicon and zirconium are the main components present (in the fibres) within variable concentration ranges b) fibres have a length weighted geometric mean diameter less two standard geometric errors of 6 or less micrometres (µm). c) alkaline oxide and alkali earth oxide (Na2O+K2O+CaO+MgO+BaO) content less or equal to 18% by weight | - | - | Carcinogenic (Article 57a) | 19/12/2011 | |
| Aluminosilicate refractory ceramic fibres | 604-314-4 | 142844-00-6 | Carcinogenic (Article 57a) | 19/12/2011 | ||
| Trilead diarsenate | 222-979-5 | 3687-31-8 | Carcinogenic (Article 57a)#Toxic for reproduction (Article 57c) | 19/12/2011 | ||
| Potassium hydroxyoctaoxodizincatedichromate | 234-329-8 | 11103-86-9 | Carcinogenic (Article 57a) | 19/12/2011 | ||
| Phenolphthalein | 201-004-7 | 77-09-8 | Carcinogenic (Article 57a) | 19/12/2011 | ||
| Pentazinc chromate octahydroxide | 256-418-0 | 49663-84-5 | Carcinogenic (Article 57a) | 19/12/2011 | ||
| N,N-dimethylacetamide | 204-826-4 | 127-19-5 | Toxic for reproduction (Article 57c) | 19/12/2011 | ||
| Lead styphnate | 239-290-0 | 15245-44-0 | Toxic for reproduction (Article 57c) | 19/12/2011 | ||
| Lead dipicrate | 229-335-2 | 6477-64-1 | Toxic for reproduction (Article 57c) | 19/12/2011 | ||
| Lead diazide, Lead azide | 236-542-1 | 13424-46-9 | Toxic for reproduction (Article 57c) | 19/12/2011 | ||
| Formaldehyde, oligomeric reaction products with aniline | 500-036-1 | 25214-70-4 | Carcinogenic (Article 57a) | 19/12/2011 | ||
| Dichromium tris(chromate) | 246-356-2 | 24613-89-6 | Carcinogenic (Article 57a) | 19/12/2011 | ||
| Calcium arsenate | 231-904-5 | 7778-44-1 | Carcinogenic (Article 57a) | 19/12/2011 | ||
| Bis(2-methoxyethyl) phthalate | 204-212-6 | 117-82-8 | Toxic for reproduction (Article 57c) | 19/12/2011 | ||
| Bis(2-methoxyethyl) ether | 203-924-4 | 111-96-6 | Toxic for reproduction (Article 57c) | 19/12/2011 | ||
| Arsenic acid | 231-901-9 | 7778-39-4 | Carcinogenic (Article 57a) | 19/12/2011 | ||
| Aluminosilicate Refractory Ceramic Fibres | are fibres covered by index number 650-017-00-8 in Annex VI, part 3, table 3.1 of Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, and fulfil the three following conditions: a) oxides of aluminium and silicon are the main components present (in the fibres) within variable concentration ranges b) fibres have a length weighted geometric mean diameter less two standard geometric errors of 6 or less micrometres (µm) c) alkaline oxide and alkali earth oxide (Na2O+K2O+CaO+MgO+BaO) content less or equal to 18% by weight | - | - | Carcinogenic (Article 57a) | 19/12/2011 | |
| 4-(1,1,3,3-tetramethylbutyl)phenol | 205-426-2 | 140-66-9 | Endocrine disrupting properties (Article 57(f) - environment) | 19/12/2011 | ||
| 2-Methoxyaniline, o-Anisidine | 201-963-1 | 90-04-0 | Carcinogenic (Article 57a) | 19/12/2011 | ||
| 2,2'-dichloro-4,4'-methylenedianiline | 202-918-9 | 101-14-4 | Carcinogenic (Article 57a) | 19/12/2011 | ||
| 1,2-dichloroethane | 203-458-1 | 107-06-2 | Carcinogenic (Article 57a) | 19/12/2011 | ||
| Strontium chromate | 232-142-6 | 7789-06-2 | Carcinogenic (Article 57a) | 20/06/2011 | ||
| Hydrazine | 206-114-9 | 302-01-2, 7803-57-8 | Carcinogenic (Article 57a) | 20/06/2011 | ||
| 2-ethoxyethyl acetate | 203-839-2 | 111-15-9 | Toxic for reproduction (Article 57c) | 20/06/2011 | ||
| 1-Methyl-2-pyrrolidone (NMP) | 212-828-1 | 872-50-4 | Toxic for reproduction (Article 57c) | 20/06/2011 | ||
| 1,2-Benzenedicarboxylic acid, di-C7-11-branched and linear alkyl esters | 271-084-6 | 68515-42-4 | Toxic for reproduction (Article 57c) | 20/06/2011 | ||
| 1,2-Benzenedicarboxylic acid, di-C6-8-branched alkyl esters, C7-rich | 276-158-1 | 71888-89-6 | Toxic for reproduction (Article 57c) | 20/06/2011 | ||
| 1,2,3-trichloropropane | 202-486-1 | 96-18-4 | Carcinogenic (Article 57a)#Toxic for reproduction (Article 57c) | 20/06/2011 | ||
| Cobalt(II) sulphate | 233-334-2 | 10124-43-3 | Carcinogenic (Article 57a)#Toxic for reproduction (Article 57c) | 15/12/2010 | ||
| Cobalt(II) dinitrate | 233-402-1 | 10141-05-6 | Carcinogenic (Article 57a)#Toxic for reproduction (Article 57c) | 15/12/2010 | ||
| Cobalt(II) diacetate | 200-755-8 | 71-48-7 | Carcinogenic (Article 57a)#Toxic for reproduction (Article 57c) | 15/12/2010 | ||
| Cobalt(II) carbonate | 208-169-4 | 513-79-1 | Carcinogenic (Article 57a)#Toxic for reproduction (Article 57c) | 15/12/2010 | ||
| Chromium trioxide | 215-607-8 | 1333-82-0 | Carcinogenic (Article 57a)#Mutagenic (Article 57b) | 15/12/2010 | ||
| Acids generated from chromium trioxide and their oligomers | - | - | Carcinogenic (Article 57a) | 15/12/2010 | ||
| Oligomers of chromic acid and dichromic acid | - | - | Carcinogenic (Article 57a) | 15/12/2010 | ||
| Chromic acid | 231-801-5 | 7738-94-5 | Carcinogenic (Article 57a) | 15/12/2010 | ||
| Dichromic acid | 236-881-5 | 13530-68-2 | Carcinogenic (Article 57a) | 15/12/2010 | ||
| 2-methoxyethanol | 203-713-7 | 109-86-4 | Toxic for reproduction (Article 57c) | 15/12/2010 | ||
| 2-ethoxyethanol | 203-804-1 | 110-80-5 | Toxic for reproduction (Article 57c) | 15/12/2010 | ||
| Trichloroethylene | 201-167-4 | 79-01-6 | Carcinogenic (Article 57a) | 18/06/2010 | ||
| Tetraboron disodium heptaoxide, hydrate | 235-541-3 | 12267-73-1 | Toxic for reproduction (Article 57c) | 18/06/2010 | ||
| Sodium chromate | 231-889-5 | 7775-11-3 | Carcinogenic (Article 57a)#Mutagenic (Article 57b)#Toxic for reproduction (Article 57c) | 18/06/2010 | ||
| Potassium dichromate | 231-906-6 | 7778-50-9 | Carcinogenic (Article 57a)#Mutagenic (Article 57b)#Toxic for reproduction (Article 57c) | 18/06/2010 | ||
| Potassium chromate | 232-140-5 | 7789-00-6 | Carcinogenic (Article 57a)#Mutagenic (Article 57b) | 18/06/2010 | ||
| Disodium tetraborate, anhydrous | 215-540-4 | 12179-04-3, 1303-96-4, 1330-43-4 | Toxic for reproduction (Article 57c) | 18/06/2010 | ||
| Boric acid | EC No. 233-139-2 and EC No. 234-343-4 | - | - | Toxic for reproduction (Article 57c) | 18/06/2010 | |
| Boric acid, crude natural | 234-343-4 | 11113-50-1 | Toxic for reproduction (Article 57c) | 18/06/2010 | ||
| Boric acid | 233-139-2 | 10043-35-3 | Toxic for reproduction (Article 57c) | 18/06/2010 | ||
| Ammonium dichromate | 232-143-1 | 7789-09-5 | Carcinogenic (Article 57a)#Mutagenic (Article 57b)#Toxic for reproduction (Article 57c) | 18/06/2010 | ||
| Acrylamide | 201-173-7 | 79-06-1 | Carcinogenic (Article 57a)#Mutagenic (Article 57b) | 30/03/2010 | ||
| Tris(2-chloroethyl) phosphate | 204-118-5 | 115-96-8 | Toxic for reproduction (Article 57c) | 13/01/2010 | ||
| Pitch, coal tar, high-temp. | - | 266-028-2 | 65996-93-2 | Carcinogenic (Article 57a)#PBT (Article 57d)#vPvB (Article 57e) | 13/01/2010 | |
| Lead sulfochromate yellow (C.I. Pigment Yellow 34) | - | 215-693-7 | 1344-37-2 | Carcinogenic (Article 57a)#Toxic for reproduction (Article 57c) | 13/01/2010 | |
| Lead chromate molybdate sulphate red (C.I. Pigment Red 104) | - | 235-759-9 | 12656-85-8 | Carcinogenic (Article 57a)#Toxic for reproduction (Article 57c) | 13/01/2010 | |
| Lead chromate | 231-846-0 | 7758-97-6 | Carcinogenic (Article 57a)#Toxic for reproduction (Article 57c) | 13/01/2010 | ||
| Diisobutyl phthalate | 201-553-2 | 84-69-5 | Toxic for reproduction (Article 57c)#Endocrine disrupting properties (Article 57(f) - human health) | 13/01/2010 | ||
| Anthracene oil, anthracene-low | - | 292-604-8 | 90640-82-7 | Carcinogenic (Article 57a)#Mutagenic (Article 57b)#PBT (Article 57d)#vPvB (Article 57e) | 13/01/2010 | Does not meet the criteria for identification as a carcinogen if it contains < 0.005 % (w/w) benzo[a]pyrene (EINECS No 200-028-5) and < 0.1 % w/w benzene (EINECS No 200-753-7). Does not meet the criteria for identification as a mutagen if it contains < 0.1 % w/w benzene (EINECS No 200-753-7). |
| Anthracene oil, anthracene paste, distn. lights | - | 295-278-5 | 91995-17-4 | Carcinogenic (Article 57a)#Mutagenic (Article 57b)#PBT (Article 57d)#vPvB (Article 57e) | 13/01/2010 | Does not meet the criteria for identification as a carcinogen if it contains < 0.005 % (w/w) benzo[a]pyrene (EINECS No 200-028-5) and < 0.1 % w/w benzene (EINECS No 200-753-7). Does not meet the criteria for identification as a mutagen if it contains < 0.1 % w/w benzene (EINECS No 200-753-7). |
| Anthracene oil, anthracene paste, anthracene fraction | - | 295-275-9 | 91995-15-2 | Carcinogenic (Article 57a)#Mutagenic (Article 57b)#PBT (Article 57d)#vPvB (Article 57e) | 13/01/2010 | Does not meet the criteria for identification as a carcinogen if it contains < 0.005 % (w/w) benzo[a]pyrene (EINECS No 200-028-5) and < 0.1 % w/w benzene (EINECS No 200-753-7). Does not meet the criteria for identification as a mutagen if it contains < 0.1 % w/w benzene (EINECS No 200-753-7). |
| Anthracene oil, anthracene paste | - | 292-603-2 | 90640-81-6 | Carcinogenic (Article 57a)#Mutagenic (Article 57b)#PBT (Article 57d)#vPvB (Article 57e) | 13/01/2010 | Does not meet the criteria for identification as a carcinogen if it contains < 0.005 % (w/w) benzo[a]pyrene (EINECS No 200-028-5) and < 0.1 % w/w benzene (EINECS No 200-753-7). Does not meet the criteria for identification as a mutagen if it contains < 0.1 % w/w benzene (EINECS No 200-753-7). |
| Anthracene oil | - | 292-602-7 | 90640-80-5 | Carcinogenic (Article 57a)#PBT (Article 57d)#vPvB (Article 57e) | 13/01/2010 | Does not meet the criteria for identification as a carcinogen if it contains < 0.005 % (w/w) benzo[a]pyrene (EINECS No 200-028-5) |
| 2,4-dinitrotoluene | 204-450-0 | 121-14-2 | Carcinogenic (Article 57a) | 13/01/2010 | ||
| Triethyl arsenate | - | 427-700-2 | 15606-95-8 | Carcinogenic (Article 57a) | 28/10/2008 | |
| Sodium dichromate | 234-190-3 | 10588-01-9, 7789-12-0 | Carcinogenic (Article 57a)#Mutagenic (Article 57b)#Toxic for reproduction (Article 57c) | 28/10/2008 | ||
| Lead hydrogen arsenate | 232-064-2 | 7784-40-9 | Carcinogenic (Article 57a)#Toxic for reproduction (Article 57c) | 28/10/2008 | ||
| Hexabromocyclododecane (HBCDD) | and all major diastereoisomers identified | - | - | PBT (Article 57d) | 28/10/2008 | |
| Hexabromocyclododecane | 247-148-4 | 25637-99-4 | PBT (Article 57d) | 28/10/2008 | ||
| gamma-hexabromocyclododecane | - | 134237-52-8 | PBT (Article 57d) | 28/10/2008 | ||
| 1,2,5,6,9,10-hexabromocyclododecane | 221-695-9 | 3194-55-6 | PBT (Article 57d) | 28/10/2008 | ||
| alpha-hexabromocyclododecane | - | 134237-50-6 | PBT (Article 57d) | 28/10/2008 | ||
| beta-hexabromocyclododecane | - | 134237-51-7 | PBT (Article 57d) | 28/10/2008 | ||
| Dibutyl phthalate (DBP) | 201-557-4 | 84-74-2 | Toxic for reproduction (Article 57c)#Endocrine disrupting properties (Article 57(f) - human health) | 28/10/2008 | ||
| Diarsenic trioxide | 215-481-4 | 1327-53-3 | Carcinogenic (Article 57a) | 28/10/2008 | ||
| Diarsenic pentaoxide | 215-116-9 | 1303-28-2 | Carcinogenic (Article 57a) | 28/10/2008 | ||
| Cobalt dichloride | 231-589-4 | 7646-79-9 | Carcinogenic (Article 57a)#Toxic for reproduction (Article 57c) | 28/10/2008 | ||
| Bis(tributyltin) oxide (TBTO) | 200-268-0 | 56-35-9 | PBT (Article 57d) | 28/10/2008 | ||
| Bis (2-ethylhexyl)phthalate (DEHP) | 204-211-0 | 117-81-7 | Toxic for reproduction (Article 57c)#Endocrine disrupting properties (Article 57(f) - environment)#Endocrine disrupting properties (Article 57(f) - human health) | 28/10/2008 | ||
| Benzyl butyl phthalate (BBP) | 201-622-7 | 85-68-7 | Toxic for reproduction (Article 57c)#Endocrine disrupting properties (Article 57(f) - human health) | 28/10/2008 | ||
| Anthracene | 204-371-1 | 120-12-7 | PBT (Article 57d) | 28/10/2008 | ||
| Alkanes, C10-13, chloro (Short Chain Chlorinated Paraffins) | 287-476-5 | 85535-84-8 | PBT (Article 57d)#vPvB (Article 57e) | 28/10/2008 | ||
| 5-tert-butyl-2,4,6-trinitro-m-xylene (Musk xylene) | 201-329-4 | 81-15-2 | vPvB (Article 57e) | 28/10/2008 | ||
| 4,4'- Diaminodiphenylmethane (MDA) | 202-974-4 | 101-77-9 | Carcinogenic (Article 57a) | 28/10/2008 |